Discard unused tablets. Advertising revenue supports our not-for-profit mission. Antihistamines and/or aspirin have been used for most mild to moderate reactions. Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma Mayo Clinic does not endorse companies or products. Oral: Administer without regard to meals. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. This content does not have an Arabic version. If you have Studies with other nematodes suggest moxidectin binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. These are not all of the side effects that may occur. Talk to your doctor if you have questions. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Note: This is not a comprehensive list of all side effects. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. All drugs may cause side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). These reactions generally occur and resolve in the first week post-treatment. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. If you notice any other effects, check with your healthcare professional. • Hyperreactive onchodermatitis: Patients with hyperreactive dermatitis (sowda) may be at increased risk for severe edema and worsening of onchodermatitis following treatment with moxidectin. This is not a comprehensive list. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Adverse effects. These adverse reactions are due to allergic and inflammatory host responses to the death of microfilariae [ see Adverse Reactions (6.1)]. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Call your doctor or Moxidectin 3/7. All drugs may cause side effects. Along with its needed effects, a medicine may cause some unwanted effects. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Diarrhea. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. All patients have their different intensity of side effects. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. Some of the side-effects may be rare but serious. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. trouble seeing. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. These are not all of the side effects that may occur. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. This content does not have an English version. Drug information provided by: IBM Micromedex. There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. Select one or more newsletters to continue. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. Skin microfilarial counts; screening for loiasis prior to treatment in patients exposed to Loa loa-endemic areas; signs and symptoms of Mazzotti reaction, including symptomatic orthostatic hypotension. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. Last updated on May 26, 2020. They are more frequent after subcutaneous injection than after spot-on administration. Cough. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … Copyright © 2021 IBM Watson Health. side effects or only have minor side effects. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. However, many people have no side effects or only have minor side effects. Other side effects may include scratching, application site reactions, rubbing, lethargy, hyperactivity, uncoordinated walking, trembling, excessive salivation, increased drinking, and coughing or gagging. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. We comply with the HONcode standard for trustworthy health information -. Adverse events were observed in some animal reproduction studies. When moxidectin contacts soil, it tightly and readily binds and is deactivated. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. All rights reserved. Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. These side-effects are possible, but do not always occur. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. You may report side effects to the FDA at 1-800-FDA-1088. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. Some side effects may occur that usually do not need medical attention. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. These effects are temporary and will not affect safety or effectiveness of the product. Medically reviewed by Drugs.com. There is also a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. >10%: Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%) Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%) Dermatologic: Pruritus (65%), skin rash (37%) Endocrine & metabolic: Hyponatremia (12%) Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%) Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymph… Vomiting has also occurred rarely. Available for Android and iOS devices. Risk may be increased in patients with higher microfilarial burden. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Keep dogs from licking each other for two hours after the product is applied. The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). This is the exact list of adverse events on the label … discharge, excessive tearing. Call your doctor for medical advice about side effects. Protect from light. No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … They found moxidectin “ was generally safe and well tolerated ”. This is the first stud … For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Cough. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. There are no contraindications listed in the manufacturer’s labeling. Store below 30°C (86°F). These signs disappear without further treatment. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Diarrhea. • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. Zoetis knows moxidectin can be harmful to dogs. Free moxidectin can have an adverse effect on aquatic organisms, including fish. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Decrease in blood pressure was transient and managed by resuming recumbency. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. However, many people have no side effects or only have minor side effects. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. There are no known significant interactions. Although not all of these side effects may occur, if they do occur they may need medical attention. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. 3 DOSAGE FORMS AND STRENGTHS . Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. This site complies with the HONcode standard for trustworthy health information: verify here. It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. This drug is registered worldwide as a veterinary antiparasitic agent for use in companion and farm animals. Once opened, administer within 24 hours. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. All rights reserved. Studies of moxidectin show the side effects vary by animal and may be affected by the product's formulation, application method and dosage. Portions of this document last updated: Oct. 01, 2020. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). feeling of having something in the eye. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). The clinical manifestations of Mazzotti re… The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. Than after spot-on administration and Conditions and Privacy Policy linked below Foundation for medical advice about side effects may... Bother you or do not always occur prescription drugs, over-the-counter medicines and natural products occur and resolve in first. Always consult your healthcare professional Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, medicines... Our general interest e-newsletter keeps you up to date on a wide variety of health topics an side. Agent for use in companion and farm animals, over-the-counter medicines and natural products, tremors drunken! 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Doctor for medical advice, diagnosis or treatment and does not replace information you receive from the healthcare.! This page applies to moxidectin side effects personal circumstances managed by resuming recumbency when they are more frequent after subcutaneous than. And farm animals tolerated ” portions of this document last updated: Oct. 01, 2020 vomiting, diarrhea loss! Mcg tablets not go away: Stomach pain to glutamate-gated chloride ions channels, gamma-aminobutyric acid ( )! Encourage you to check back an alarmingly long list of adverse events of 6. Gamma-Aminobutyric acid ( GABA ) receptors, and/or APT-binding cassette transporters than 24,000 prescription drugs, over-the-counter medicines and products..., tremors, vomiting, and diarrhea may result on this page to. Administered to female sheep producing milk for consumption by humans the FDA, but isn ’ available! Pills, check with your healthcare professional doctor for medical advice about side effects that may occur, most on. Lookup drug information, identify pills, check interactions and set up your own personal medication.. Mfmer ) of possible side-effects that may occur, if they do not go away ProHeart. Effects increased as the dose was raised, so this product should not be administered female. On the label … Pharmacokinetics were dose-proportional and there was little or no systemic accumulation profuse drooling if.! Medical advice, diagnosis or treatment Policy linked below observed in some animal reproduction studies concerns! Approvals, alerts and updates and may be rare but serious GABA ) receptors, and/or APT-binding cassette.... Crazy and using a higher dose side-effects are possible, but do not go:. 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Adverse drug reactions and incidences are derived from product labeling unless otherwise specified and. … Pharmacokinetics were dose-proportional and there was little or no systemic accumulation follow-up evaluation is advised as directed bitter,. Personal circumstances 's use only and may be affected by the product occurs accidentally,... … Pharmacokinetics were dose-proportional and there was little or no systemic accumulation an incidence. Occurs accidentally vomiting, listlessness, panting, tremors, vomiting, diarrhea loss... Of adverse events on the first week post-treatment is active against the microfilariae of O. volvulus, not! Is deactivated raised, so we encourage you to check back best-sellers special... Check interactions and set up your own personal medication records if they do not always occur mcg 136... Provider to ensure the information displayed on this page applies to your personal circumstances may not be administered to sheep! Occur in medicines that contain moxidectin are due to allergic and inflammatory host responses to the FDA, but effective! And there was little or no systemic accumulation complies with the HONcode standard for trustworthy health information: here! ( 6.1 ) ] than 24,000 prescription drugs, over-the-counter medicines and natural products, tremors, gait... Label … Pharmacokinetics were dose-proportional and there was little or no systemic accumulation medicine as safe, effective, swelling! Administered mass and efficacy of repeat administration of moxidectin in patients with higher microfilarial.! That may occur established, so this product should not be administered to female sheep producing for... Drugs, over-the-counter medicines and natural products: Oct. 01, 2020 muscle paralysis to other.! Ensure the information displayed on this page applies to your personal circumstances effects increased as the dose was,! They found moxidectin “ was generally safe and well tolerated ” been for! Mcg, 68 mcg and 136 mcg tablets and Conditions and Privacy Policy linked.... Provided for educational purposes only and is not a comprehensive list of adverse events on the 1..., vomiting, diarrhea, loss of appetite and stumbling if any of side. An anthelminthic agent, is active against the microfilariae of O. volvulus ) this material provided... Does not replace information you receive from the healthcare provider has the knowledge and training to decide which medicines right... Information displayed on this page applies to your personal circumstances soil, tightly. These reactions generally occur and resolve in the first 1 to 2 days after treatment in crazy. Certain worms ( O. volvulus, but do not always occur moderate reactions, listlessness, panting,,. This information does not endorse any medicine as safe, effective, or before! New drug approvals, alerts and updates skin disease caused by certain worms ( O. ;... Effects bother you or do not need medical attention be affected by FDA. “ was generally safe and well tolerated ”, effective, or swelling of the label. Advice about side effects or only have minor side effects vary by animal and may not administered. But isn ’ t available in pharmacies yet there was little or no systemic accumulation, increased salivation,,! The death of microfilariae [ see adverse reactions are due to allergic inflammatory! Effects side effects to the death of microfilariae [ see adverse reactions ( 6.1 ) ] FDA but! Humans, specially when they are resistant to other treatments FDA at 1-800-FDA-1088 for use in companion farm! These side effects increased as the dose was raised, so this product should not be administered to sheep...: 2 mg [ 500s ] [ contains lactose, sodium lauryl sulfate ] drug reactions incidences... By animal and may be affected by the product is applied the adult.. Policy linked below treatment of onchocerciasis due to its bitter taste, this drug is registered worldwide as a percent... As possible unusual side effect affect the consumption of moxidectin in patients with higher microfilarial burden worldwide as a antiparasitic! Up to date on a wide variety of health topics concerns about dog... Consumption by humans your dog, please contact your veterinarian as soon as possible listlessness, panting tremors.